Project for Systems Biology of Microorganisms, MMRC, Chiba University.

Research

Our laboratory explores the molecular foundations of pathogenic fungi. We aim to clarify how the host immune system responds to fungal infections, reveal the mechanisms by which fungi develop drug resistance, and develop innovative therapeutic strategies based on genomic data. As the number of immunocompromised patients continues to rise, fungal infections are becoming an increasingly serious public health issue. To address this challenge, we investigate how fungi interact with and evade the host immune system, and examine the molecular basis of antifungal drug resistance emerging in clinical settings.

Furthermore, by using genomic analysis with next-generation sequencing technologies, we are uncovering genetic networks that underlie diversity, evolutionary adaptation, and drug resistance of pathogenic fungi. This work not only enhances diagnostic accuracy and supports the development of personalized medicine, but also contributes to the discovery of new therapeutic targets. Building on these findings, we aim to translate molecular-level insights into clinical applications, helping to develop innovative strategies for combating fungal infections.

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